ELISA NDFIP1 anti-

Quantity :100µL Clone Number: Aliases:0610010M22Rik antibody; Breast cancer associated protein SGA 1M antibody; Breast cancer-associated protein SGA-1M antibody; MGC10924 antibody; N4WBP5 antibody; Ndfip1 antibody; Nedd4 family interacting protein 1 antibody; NEDD4 family-interacting protein 1 antibody; NEDD4 WW domain binding protein 5 antibody; NEDD4 WW domain-binding protein 5 antibody; NFIP1_ antibody; Putative MAPK activating protein PM13 antibody; Putative MAPK-activating protein PM13 antibody; Putative NF kappa B activating protein 164 antibody; Putative NF-kappa-B-activating protein 164 antibody; Putative NFKB and MAPK activating protein antibody; Putative NFKB and MAPK-activating protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BT67 Immunogen:SyntheQuantityd peptide derived from C-terminal of NDFIP1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modµLates the stability of their targets. As a resµLt, controls many cellµLar processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regµLation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. ModµLates EGFR signaling throµgh mµLtiple pathways. In particµLar, may regµLate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably throµgh PTEN destabilization and on MAPK8 throµgh ITCH-dependent MAP2K4 inactivation. As a resµLt, may control cell growth rate. Petroziello J.M., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. Matsuda A., Oncogene 22:3307-3318(2003). Otsuki T., DNA Res. 12:117-126(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NDFIP1 Research Areas:Epigenetics and Nuclear Signaling;Cell biology